In the mid-1990s, University of Cambridge biochemists David Klenerman and Shankar Balasubramanian were trying to solve a fundamental problem: how to watch a single DNA polymerase molecule at work. Their approach used modified nucleotides, called reversible terminators, tagged with four different colors of fluorescent molecules. If one of these “terminators” was grabbed by the DNA polymerase and incorporated onto the replicating DNA strand, it would block the addition of any other bases until removed using a separate chemical reaction.
Hall’s chief deputy at the time, John Ford, told me that the arrest “was a holy shit moment,” adding, “He’s been in and out of our jails, he’s been in meetings with us, and he’s doing this—right behind our backs?” Ford didn’t know what Friedmann had been up to in the jail, but sensed that he “was getting ready” to commit an awful crime.
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He said the Saturday was the "worst day", and added "there was a lot of bombs going".
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