Non-plant related construction broke ground at the Wyoming facility in June 2024. | Image: TerraPower
In 2006, 454 collaborated with Swedish paleogeneticist Svante Pääbo to sequence the first million base pairs of the Neanderthal genome; the project would be completed four years later, albeit with some help from Illumina sequencing. Illumina and other subsequent NGS technologies rendered pyrosequencing non-competitive, and in 2013, 454 was shut down by Roche, which had acquired it six years earlier. The technology is still used today for some applications, but most importantly, it was the first commercially viable alternative to Sanger sequencing, and the first sequencing method that could be fully automated because it didn’t rely on gels or other tedious steps.
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这一理念也是国际通行的准则。全球报告倡议组织（GRI）标准中也专门设有“营销与标识”议题，要求报告因产品信息与标识、营销传播违规而引发的事件。香港交易所的《环境、社会及管治报告指引》要求企业披露关于产品健康与安全、广告、标签的政策及合规情况。